Mycetoma-like phaeohyphomycosis treated with terbinafine

Mycetoma

A 32-year-old woman from northeastern Brazil worked in farming and presented with a 6-year history of progressive swelling of the left foot. Swelling and sinuses draining purulent discharge with white grains ( Figure 1 ) were present. Potassium hydroxide preparation of drainage showed whiteyellowish nodules with fine filaments. Culture of the grains on Sabouraud agar and the casein hydrolysis t...

Subcutaneous phaeohyphomycosis due to Phialemoniopsis ocularis successfully treated by voriconazole

We report a case of subcutaneous infection in a 67 year-old Cambodian man who presented with a 5-month history of swelling of the right foot. Histopathology was compatible with phaeohyphomycosis and the hyphomycete Phialemoniopsis ocularis was identified by the means of morphological and molecular techniques. The patient responded well to a 6-month oral treatment with voriconazole alone.

Mycetoma

Mycetoma is a chronic infective condition of tropical and subtropical regions. It is commoner in males, especially those in their third or fourth decade who work on the land. The clinical triad of subcutaneous nodule, sinuses and discharge usually leads to diagnosis; the disease is commonly painless. Treatment is by extensive surgical excision of affected areas and may include limb amputation. ...

Possible carbamazepine toxicity with terbinafine.

OBJECTIVE To report a case of carbamazepine and terbinafine interaction resulting in an elevated level of carbamazepine and associated symptoms of toxicity. CASE SUMMARY A 50-year-old Caucasian man developed an elevated carbamazapine level after starting terbinafine, which caused symptoms of toxicity with gait ataxia, dizziness and falls. DISCUSSION This is a first report of a drug-drug int...

Subcutaneous phaeohyphomycosis in a renal transplant recipient successfully treated with voriconazole.